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Activated because of the antibiotic rifampicin and many plant metabolites, like hyperforin, guggulipid, colupulone, and isoflavones. Response to particular ligands is species-precise. Activated by naturally transpiring steroids, like pregnenolone and progesterone. Binds into a reaction aspect within the promoters with the CYP3A4 and ABCB1/MDR1 gene